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It has been previously mentioned that Masteron holds a moderate anabolic strength rating, making it only ever so slightly stronger than Testosterone, and in some cases may be weaker(1). Masteron was originally developed as a low-protein prepping supplement for bodybuilders in order to improve testosterone levels (9). It is believed that the enzyme glutamine synthetase is responsible for the creatine metabolism with other creatine is broken down in liver. The creatine was then oxidised with the help of ATP, resulting in the formation of glutamine synthetase. This compound is essential in the metabolism of creatine which aids in the maintenance of high muscle mass and therefore can improve creatine uptake in tissues. It does not raise muscle protein content, is non-toxic and has anti-catabolic properties in regards to muscle maintenance (10), it can also increase fat burn and burn fat during anabolic periods.
It is known that Masteron supplementation is a very safe supplement in comparison with other anabolic steroids because it does not increase liver enzymes (11). It is thought that Masteron is metabolised in the liver by the same enzymes that breakdown other anabolic steroids. It cannot raise muscle protein content which is essential for muscle recovery.
Since the introduction of Masteron, several studies have been conducted on its use against steroid use disorders. However, its success in preventing or treating steroid misuse still falls short compared to other a legal drug. The current meta review found that Masteron’s effectiveness against abuse of the anabolic steroids was between half and one-third of other steroids that are also used for recreational purposes (12). In a meta-analysis of all studies on Masteron’s effectiveness of prevention against addiction to or misuse of the anabolic steroids, there was no significant difference when compared with placebo (13). In a review of the clinical effectiveness and tolerability of Masteron, it was found that over 100 patients have taken Masteron over the last decade, mostly as supplemental use for improving performance and improving overall health in athletes and bodybuilders (14).
In the following section, this review explains how Masteron works and how it can be useful for athletes and bodybuilders.
Effect on Anabolic Steroids:
Masteron stimulates the synthesis of glutamine from glutamate and creatine (15). Glutamine synthase is an essential enzyme for the creatine metabolism. It is widely accepted as the primary source of glutamine in the body, therefore a high glutamine supply is crucial for optimal creatine concentrations. The synthesis of glutamine depends on the glutaminase enzyme which is also implicated in the synthesis of creatine.
Since glutamine is a nitrogen-based amino acid that serves as precurs
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